ITCC - Innovative Therapies for Children with Cancer in Europe

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    for Children with Cancer in Europe
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  • Phase 1b/2 Study of Carfilzomib in combination with Dexamethasone, Mitoxantrone, PEG-asparaginase, and Vincristine (R3 Induction Backbone) in pediatric subjects with relapsed or refractory Acute...

  • A phase I/II study of Bosutinib in pediatric patients with Chronic Myeloid Leukemia who are resistant or intolerant to at least one prior Tyrosine Kinase Inhibitor therapy


    Solid Tumor

    Phase I-II Study of Vinblastine in combination with Nilotinib in children and adolescents with refractory or recurrent low-grade glioma : A SIOP and ITCC protocol


    Solid Tumor

    A randomised phase IIb trial of BEvACizumab added to Temozolomide ± IrinOtecan for children with refractory/relapsed Neuroblastoma

  • Phase I open label, dose escalation trial to determine the MTD, safety, PK and efficacy of afatinib monotherapy in children aged 2 years to <18 years with recurrent/refractory neuroectodermal...


    Solid Tumor

    Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication : BIOMEDE

  • A Phase I/II, Multicenter, Open-Label, dose‑escalation Study of the Safety and Pharmacokinetics of Cobimetinib in Pediatric and Young Adult Patients with Previously treated Solid Tumors

  • ITCC-053 CRISP

    Solid Tumor

    A phase IB study of crizotinib (Xalcori®) in pediatric malignancies with anaplastic lymphoma kinase (ALK) aberrations

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