ITCC PROJECTS
Clinical Trials
Ongoing
| ITCC-006 | BO20924 | A Study of Avastin (Bevacizumab) in Combination With Standard Chemotherapy in Children and Adolescents With Sarcoma |
| ITCC-008 | Forodesine | A Phase I/II Pharmacokinetic Study of Intravenous and Oral Forodesine in Children with Relapsed or Refractory T-cell or B-cell Precursor Acute Lymphoblastic Leukaemia or T-cell Non-Hodgkin’s Lymphoma |
| ITCC-009 | A5961166 | Phase 2 Single-Arm, Open Label Study Of Irinotecan In Combination With Temozolomide In Children With Recurrent Or Refractory Medulloblastoma And In Children With Newly Diagnosed High-Grade Glioma |
| ITCC-013 | TOTEM 2 | Phase 2 Single-arm Study of Temozolamide in combination with Topotecan in refractory and relapsed Neuroblastoma and other Paediatric Solid Tumours |
| ITCC-017 | Dasatinib 226 | A Phase II Study of Dasatinib Therapy in Children and Adolescents with Ph+ Leukemia with Resistance or Intolerance to Imatinib |
| ITCC-020 | Clofarabine-DNX | A Phase I/II study of clofarabine in combination with cytarabine and liposomal daunorubicin in children with relapsed/refractory pediatric AML |
| ITCC-024 | PK412 | A phase I/II, open-label, dose-escalating study to evaluate the safety, tolerability and pharmacokinetics of twice daily oral midostaurin and to evaluate the preliminary clinical and pharmacodynamic response in pediatric patients with relapsed or refractory leukemia |
Trials on papers
- Population pharmacokinetics and pharmacogenetics of imatinib in children and adults, Clin Cancer Res. 2008 Nov 1;14(21):7102-9.
- Target-driven exploratory study of imatinib mesylate in children with solid malignancies by the Innovative Therapies for Children with Cancer (ITCC) European Consortium, Eur J Cancer. 2009 Apr 9
Closed Trials
ITCC 001 - GLIVEC® : The study recruited 36 patients
from 16 centres. The results of the study were presented in ASCO 2006,
SIOP 2006 and EORTC/NCI/AACR 2006 meetings.
This study is the living proof that ITCC is able to recruit patients in
Phase II in a timely fashion.
Abstract of the study : Glivec ITCC1 abstract study